THE PROSPECTS AND CHALLENGES OF CRISPR/CAS9 GENE EDITING IN CANCER THERAPY: A LITERATURE REVIEW

Relevance: Cancer remains one of the leading causes death in Kazakhstan, and CRISPR/Cas9 offers possible solutions to treat it. Clustered, regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9) is a system bacteria use cleave foreign in-vaders. This has been considered promising for cancer therapeutics by allowing researchers edit cell genes.
 The requires more trials, so it essential raise awareness this technique stu-dents potential investors highlight current challenges that could be research opportuni-ties researchers.
 study aimed analyze provide up-to-date information from reputable scientific journals on medical students researchers. paper also highlights associated with implementing clinical settings therapeutics.
 Methods: literature databases (PubMed Nature Journal) were searched analyzed using therapy.
 Results: results indicate scientists should focus improving types structure Cas as well delivery methods, including non-viral deliv-ery methods (liposome-based particles, hybrid vectors, gold nanoparticles, extracellular vesicles) contribute status Conclusion: an important still fraught turned into opportunities. include form nuclease, engineering (in vivo vs. ex vivo), varieties methods. Each method type pros cons further research. In particular, future studies such liposome-based vesi-cles, vesicles, nanoparticles.